2021.10.20 12:58 h0neysuga unhealthy obsession with a guy
so him and i did a lot of intimate things. he knows that i like him but he likes my best friend. they also had some intimate moments together. were all pretty open abt the situation but i am incredibly jealous even though i dont rlly have the right to. i cry over him a lot and have a lot of suicidal thoughts and some rlly close attemps bc of the situation. ive become pretty obsessed with him, i am very much aware. it has come to the point where i dont get turned on by anything other than thinking abt him. porn doesnt do anything anymore. i dont wanna ruin his chances with my friend tbh but i cant stand it. i could cut off all contact bc he lives a few hours away, but i dont really want to. the friendship in itself is fun and i dont wanna ruin that.
if you have any advice on what to do, please tell me. were both 16
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2021.10.20 12:57 According_Dog6735 Johnkaz34s Lead declining after sucide scandal
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2021.10.20 12:57 TheShinning44 The combo of the Queue and the connection bug if you fail to join a game is broken
Just waited 20 min in queue, did one baal run, next one didn't start yet so when I typed in the name it failed to join, then get the connection error, and then get to go back to sitting in the queue cause I need to restart the game. OP
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2021.10.20 12:57 chmilz Alberta premier says he will work with new mayors of Calgary and Edmonton
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2021.10.20 12:57 HeII_Boy Simps on tinder is another level
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2021.10.20 12:57 DraftAngel Native girl from an anatomy study!
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2021.10.20 12:57 eclarenebby a field of monsteras at the Los Angeles County Arboretum
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2021.10.20 12:57 itzyani_04 Gunman who killed 17 in Parkland, Florida, in one of deadliest US school shootings pleads guilty of murder and could face death penalty.
2021.10.20 12:57 mjsather How cold is too cold for 100 mile ride?
I know… another post about a century. Sorry.
A friend and I are planning on attempting our first century this weekend. The farthest I’ve gone is 50 miles, and my friend is in better shape than I am.
My question is, how cold is too cold? It’s looking like 47 degrees for a high and 35 in the morning. Is this crazy to do for our first century? Are there any good ways of storing clothes on a road bike in case we take some off? Or just some other tips? What do other people wear for this kind of trip?
I’m anticipating putting wind guards on my shoes, smart wool socks, couple layers on my legs, not sure for the top yet, hat, helmet, and gloves.
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2021.10.20 12:57 newsdk Sikandar Siddique siger, at der er had og racisme mod især den muslimske minoritet – og kræver handling fra statsministeren
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2021.10.20 12:57 airmaxed- Eli5 - how does a car engine work??
2021.10.20 12:57 JHNSN3RD This wedding photo I took capture some dancer’s incredibly long arm!
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2021.10.20 12:57 viewfromtheclouds Photopass Refund?
2021.10.20 12:57 paintandwood Curious about the little fruits!?
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2021.10.20 12:57 MEETMEONLINE Sorrento Therapeutics Inc. (NASDAQ: SRNE) Receives Approval to Proceed with ESG-401 and Resinferatoxin Studies By Kate Hudson -October 20, 2021
Sorrento Therapeutics Inc. (NASDAQ: SRNE) had initially announced that its subsidiary Levena (Suzhou) Biopharma Cop. Ltd and its partner Escugen Biotechnology Co. Ltd had received an authorization letter from the National Medical Products Administration’s Centre for Drug Evaluation for the application for clinical trials of recombinant humanize anti-trop2 Mab-SN38 conjugate (ESG-401).
Sorrento receives FDA clearance to proceed with ESG-401 studied Now, Sorrento has announced that the US FDA has issued clearance to continue with clinical trials in patients with refractory or relapsed solid tumors. ESG-401 addresses unmet needs for multiple solid tumors treatment that include urothelial carcinoma and triple-negative breast cancer.
Also, the FDA has given Sorrento cleared to continue with the global Phase 2 clinical trial of resiniferatoxin. The study is entitled, “A Multicenter, Phase 2 Study to Assess the Safety and Efficacy of Epidural Resiniferatoxin for the Treatment of Intractable Pain Associated with Advanced Cancer.” The double-blind, multicentre, controlled trial will evaluate the “efficacy and safety of several RTX doses vs. placebo controls to manage intractable pain in up to 120 patients with advanced cancer.” Over the course of a year, three RTX dose groups (15, 20, and 25 mcg) will be compared to vehicle control and concurrent control groups.
Procedural pain most prevalent adverse event following resiniferatoxin administration
This indication’s conclusions are based on a review of the significant observations from the Phase 1b study results (NCT03226574). Notably, the Phase 1 trial evaluated the safety and preliminary efficacy of epidural administration of resiniferatoxin for cancer-related intractable pain treatment in 17 individuals. After epidural administration of RTX at dosages up to 30 mcg, the most prevalent adverse event was “procedural pain,” which was experienced by just over half of the patients (52.9%). All of these occurrences were of mild severity and lasted only a few hours. In nearly all of the participants, pharmacokinetic sampling revealed no detectable systemic RTX levels.
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2021.10.20 12:57 JennyMelody Sorry for late post 3 Here the requested smols, you can requests them today again, this time because of late post you can do it till Midnight GMT+2
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2021.10.20 12:57 ProcessPatient Just diagnosed today
Had a FNA a week ago. Doctor had me come in to tell me. Was relieved at first because I’ve had so many strange symptoms. Now I’m a bit worried. I remember things like a year ago I had a swollen lymph node on my neck very briefly. But overall I’m doing alright. No idea on spread or etc. But thyroid cancer seems treatable from what I’ve read. How’re y’all? It’s really weird telling my family honestly.
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2021.10.20 12:57 carol_eliza Wendy the popstar sheep is in boxes!
2021.10.20 12:57 Psychological-Lake73 Karla/Karura seems pretty THICC
2021.10.20 12:57 Scheiblerfunk Fanfic Reading | Chapter 1 | The Lion King 2 "Pound of Flesh" by Shembre
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2021.10.20 12:57 brokemember [US-IL][H] PayPal [W] BIIP MT3 EXTENDED 2048 Ergo (Few specific keys)
Looking for these specific keys from the BIIP MT3 EXTENDED 2048 Ergo set.
Pretty flexible on the color vs non colored version of the keys shown.
So if you have a preference for one over the other then let me know.
I just selected the colored ones to display in the picture.
Even if not all of those keys are available, I am still willing to work something out.
PS: If you have other ones from those particular rows then still pm me to see if I can use them.
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2021.10.20 12:57 amanimaedesign Positive ovulation on Clear Blue, but LH sticks show negative? Cycle day 12.
I'm currently on CD 12. My AF was from CD 1-5 and I started tracking my ovulation on CD 9 (am and pm).
I have been using the Clearblue Digital Ovulation test, and I have also been using regular LH sticks.
Today, my Clearblue shows high ovulation (blinking smiley!). However, the LH sticks still show no progression at all since CD 9. Is there a reason for this?
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2021.10.20 12:57 richbmfg Should’ve kept my safemoon in the trust wallet it’s up $75 more than in safemoon wallet.
2021.10.20 12:57 connardnumero1 Do you think it's possible, as of today, to program a bot as good as pro players ?
2021.10.20 12:57 mJ_777 Yes, it's big brain time
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